|
|
|
Adhatoda
vasica |
|
| CHEMICAL
COMPOSITION |
The
leaves of the plant contain two major alkaloids called vasicine, and vasicinone1,2. |
| PHARMACOLOGY |
The
active alkaloid vasicine and its autooxidation product vasicinone have shown
bronchodilator and antihistaminic effects3,4. Uterine stimulant
activity and moderate hypotensive activity of the alkaloids were reported. Thrombopoeitic
activity of vasicine has been observed5. Intraamniotic injection
of vasicine hydrochloride was effective in inducing mid-trimester abortions at dose of
60mg6. |
| THERAPEUTIC
USES |
The leaf
extract has been used for the treatment of bronchitis and asthma for many centuries. It
relieves cough and breathlessness7. It is also prescribed
commonly for bleeding due to idiopathic thrombocytopenic purpura, local bleeding due to
peptic ulcer, piles, menorrhagia etc. Its local use gives relief in pyorrhoea and in
bleeding gums8. |
| REFERENCES |
- Pandita, K: Planta Med,
48:81 (1983).
- Atal, C.K. : Chemistry and
Pharmacology of vasicine - A new oxytocic and abortifacient, P.58., New Delhi(1980).
- Chopra, R.N. : Indigenous
Drugs of India, Academic Publishers, Calcutta (1982).
- Amin, A.H. and D.R Mehta :
Nature, 184:1317 (1959).
- Atal, C.K. et al. : Ind. J.
Exp. Biol., 20:704 (1982).
- J. Obstet, Gynaecol. India
1979, 29, 939.
- Gogate, V.M. :
Dravyagunavignyana, continental prakashan, Pune (1982)
- Doshi, J.J. et al. : Int. J.
Crude Drug Res., 21:173(1983).
|
SPECIFICATIONS:
ADHATODA VASICA EXTRACT
General
Information:
| Type of extract |
: |
Dry powder |
| Plant parts used |
: |
Leaves |
| Source |
: |
Wild crafted |
| Shelf life |
: |
24 months unopened |
| Storage |
: |
Keep in a cool, dry
place protected from moisture and heat |
| Active ingredient/s |
: |
Vasicine and
Vasicinone |
| Method of analysis |
: |
HPLC |
Analytical
Specifications :
| Description |
: |
Light brown powder with hygroscopic nature |
| Organoleptic characters |
: |
Bitter in taste with characteristic odour |
| Loss on drying |
: |
Not more than 5% W/W |
| Lead |
: |
Not more than 10 PPM |
| Arsenic |
: |
Not more than 2 PPM |
| Heavy metals |
: |
Not more than 20 PPM |
| Assay |
|
|
| a) Vasicine content on dry basis by HPLC |
: |
Not less than 0.5% W/W |
| b) Vasicinone content on dry basis by HPLC |
: |
Not less than 0.25% W/W |
| Microbiological profile |
|
|
| Total bacterial count |
: |
Not more than 10000 CFU/gm |
| Yeasts and moulds |
: |
Not more than 100 CFU/gm |
| E.coli |
: |
Absent |
| S.aureus |
: |
Absent |
| Salmonella typhi |
: |
Absent |
| Pseudomonas aeruginose |
: |
Absent |
* Adhatoda vasica extract is also
available with >95% w/w Vasicine and >95% w/w
Vasicinone |
|
