|
|
 |
Andrographis paniculata |
|
| CHEMICAL
COMPOSITION |
Three bitter principles, deoxyandrographolide, andrographolide
and neoandrographolide have been isolated from the whole plant and leaves1. |
| PHARMACOLOGY |
The hepatoprotective effect of the water extract of the plant
and the active principle andrographolide has been studied 2.
Both leaf extract and andrographolide in a single oral dose also inhibited the microsomal
lipid peroxidation induced by carbon tetrachloride3. The effect
of aqueous extract on the bile flow in albino rats was compared with phenobarbitone.
Significant increase in liver weight was also observed4. |
| THERAPEUTIC
USES |
It is used in loss of appetite in infants and also used as a
febrifuge, stomachic, tonic, alterative, anthelmintic,antispasmodic etc. 5.
It is chiefly used in viral hepatitis, diminished appetite and drug induced liver damage1.
|
| REFERENCES |
- Selected Medicinal Plants of India, CHEMEXCIL, Mumbai (1992)
- Govindachari, T.R.et al.:Ind.J.Chem.,7:306, (1969)
- Roy Chaudhuri B. and M.K.Podar: Methods Find.Exp.Clin.
Pharmaacol.,6:9,(1984)
- Chaudhuri, S.K.:Ind.J.Exp.Biol., 16"7, (1978)
- Dictionary of Indian Medicinal Plants, CIMAP, Lucknow (1992)
|
| SPECIFICATIONS: ANDROGRAPHIS
PANICULATA EXTRACT
General
Information:
| Type of extract |
: |
Dry powder / thick paste |
| Plant parts used |
: |
Whole plant |
| Source |
: |
Wild crafted |
| Shelf life |
: |
24 months unopened |
| Storage |
: |
Keep in a cool, dry
place protected from moisture and heat |
| Active ingredient |
: |
Andrographolides |
| Method of Analysis |
: |
HPLC/HPTLC |
Analytical
Specifications :
| Description |
: |
Brownish green powder with hygroscopic nature |
| Organoleptic characters |
: |
Extremely bitter in taste with characteristic aroma |
| Loss on drying |
: |
Not more than 5% W/W |
| Lead |
: |
Not more than 10 PPM |
| Arsenic |
: |
Not more than 2 PPM |
| Heavy metals |
: |
Not more than 20 PPM |
| Assay |
|
|
| Andrographolides content on dry basis by HPLC/HPTLC |
: |
Not less than 8% w/w |
| Microbiological profile |
: |
|
| Total bacterial count |
: |
Not more than 10000 CFU/gm |
| Yeasts and moulds |
: |
Not more than 100 CFU/gm |
| E.coli |
: |
Absent |
| S.aureus |
: |
Absent |
| Salmonella typhi |
: |
Absent |
| Pseudomonas aeruginose |
: |
Absent |
|
|
