|
|
 |
Coleus
forskohlii |
|
| CHEMICAL
COMPOSITION |
Forskolin
has been found to be the main active constituent of the roots1,
though many other diterpenoids viz. deacetyl forskolin, 9-deoxyforskolin, 1,
9-deoxyforskolin,1, 9-dideoxy- 7-deacetylforskolin along with four minor diterpenoids have
been reported2. |
| PHARMACOLOGY |
Forskolin
reduces preload and afterload of the heart due to its vasodilating action and augments
myocardial contractility due to its positive inotropic action without affecting myocardial
oxygen consumption.Forskolin relaxed contracted airways in-vitro and
prevented methacholine and acetylcholine induced bronchoconstriction in asthmatics and
healthy subjects respectively3. It shows blood pressure lowering
and cardioactive properties4. |
| THERAPEUTIC
USES |
It is
used as a cardiac tonic. It is indicated to lower the blood pressure4. |
| REFERENCES |
- Tondon,J.s. and Dhar.M.M.,
Ind.J.Chem., 1977; 15B:880-883.
- Gabetta.B.,Zin.G. and
Danoeli.B.Phytochemistry,1989;28(3):859-862.
- De Souza N.J and Shah V.In
"Economic and Medicinal Plant Research", Wagner,H., Hikino, H. and
Fransworth,N.R.ed., Academic Press, London 1988; 2: 1-16.
- Tetrahedron Lett. 1977,1669.
|
| SPECIFICATIONS: COLEUS
FORSKOHLII EXTRACT
General
Information:
| Type of extract |
: |
Dry powder |
| Plant parts used |
: |
Roots |
| Source |
: |
Wild crafted |
| Shelf life |
: |
24 months unopened |
| Storage |
: |
Keep in a cool, dry
place protected from moisture and heat |
| Active ingredient/s |
: |
Forskolins |
| Method of analysis |
: |
HPLC |
Analytical
Specifications :
| Description |
: |
Dark brown powder,highly hygroscopic |
| Organoleptic characters |
: |
Aromatic in
taste with characteristic odour |
| Loss on drying |
: |
Not more than 5% W/W |
| Lead |
: |
Not more than 10 PPM |
| Arsenic |
: |
Not more than 2 PPM |
| Heavy metals |
: |
Not more than 20 PPM |
| Assay |
|
|
| Forskohlins content on dry basis by HPLC |
: |
Not less than 10% W/W |
| Microbiological profile |
|
|
| Total bacterial count |
: |
Not more than 10000 CFU/gm |
| Yeasts and moulds |
: |
Not more than 100 CFU/gm |
| E.coli |
: |
Absent |
| S.aureus |
: |
Absent |
| Salmonella typhi |
: |
Absent |
| Pseudomonas aeruginose |
: |
Absent |
* Coleus forskohlii extract is
also available with >1%and >95%w/w Forskolins. |
|
