|
|
 |
Glycyrrhiza
glabra |
|
| CHEMICAL
COMPOSITION |
The main constituents are glycyrrhizin, the
potassium and calcium salts of glycyrrhitinic acid. Flavonoid rich fractions include
liquirtin, isoliquertin, liquiritigenin and rhamnoliquirilin1. |
| PHARMACOLOGY |
Extensive reports are available on modern
pharmacological research on this drug supporting its claims in older literature as a broad
spectrum entity in many pharmacopoeias.Recent studies report the antiinflammatory action
of glycyrrhetinic acid2. Both liquorice extract and
glycyrrhetinic acid are shown to have desoxycorticosterone3 and
ACTH-like effects, though with less toxicity than cortisone4,
encouraging its use as an antiarthritic agent5, in addisions
disease6 and simmonds disease7. It
prevented the development of experimental cirrhosis in rats8. It
is also found to be of much use as an antioxidant9
antihepatotoxic agent10. |
| THERAPEUTIC
USES |
In Ayurveda, it is used extensively as a
demulcent, mild expectorant and antiinflammatory agent. It is indicated in sore throat
with hoarseness of voice and cough, acid peptic disease, chronic liver disease, and as a
general tonic. |
| REFERENCES |
- Shibata et al: Chem. Pharma. Bull. 26:144, 1978.
- Iketa T. : Nippon Kosholnin kagakkushu 8(1) : 67 (1984)
- Li Sheng Chang et al: Jen Min Pao chien 3:235, 1959.
- Ito K et al: Bull Pharma. res. Inst. (Japan) 10:35, 1955.
- Gujral M.L. and P.N.Saxena, Ind.J.Med.Res. 44,657,1958.
- Groen J et al: New Eng. J. Med. 244,471,1951.
- Borst J. G.G. et al: Lancet 264,657,1953.
- Hennemann, H. and G. Kunnert, Pharmazie 8:463 (1953)
- Kiso Y. et al: Planta Med. 2,50,1985.
- Zhao M.Q. et al: Acta Pharm Sin 18,325,1983.
|
| SPECIFICATIONS: GLYCYRRHIZA
GLABRA EXTRACT
General
Information:
| Type of extract |
: |
Dry powder |
| Plant parts used |
: |
Roots |
| Source |
: |
Wild crafted |
| Shelf life |
: |
24 months unopened |
| Storage |
: |
Keep in a cool, dry
place protected from moisture and heat |
| Active ingredient |
: |
Glycyrrhizinic acid |
| Method of analysis |
: |
As per Indian
Pharmacopoeia 1996,followed by HPTLC |
Analytical
Specifications :
| Description |
: |
Brown powder |
| Organoleptic characters |
: |
Sweet in taste with characteristic odour |
| Loss on drying |
: |
Not more than 5% W/W |
| Lead |
: |
Not more than 10 PPM |
| Arsenic |
: |
Not more than 2 PPM |
| Heavy metals |
: |
Not more than 20 PPM |
| Assay |
|
|
| Glycyrrhizinic acid content on dry basis by HPTLC |
: |
Not less than 25% W/W |
| Microbiological profile |
: |
|
| Total bacterial count |
: |
Not more than 3000 CFU/gm |
| Yeast and moulds |
: |
Not more than 100 CFU/gm |
| E.coli |
: |
Absent |
| S.aureus |
: |
Absent |
| Salmonella typhi |
: |
Absent |
| Pseudomonas aeruginose |
: |
Absent |
|
|
