Guggul
(Commiphora Mukul)
CHEMICAL COMPOSITION Guggul resin contains a number of compounds- a diterpene hydrocarbon, a diterpene alcohol, Z-gugulsterone, E-gugulsterone,guggulsterol-I, Guggulsterol-II, guggulsterol-III 1.
PHARMACOLOGY The two main areas of investigation have been its hypolipidaemic action, which has been recognised since the vedic ages and its antiinflammatory effect. Oral administration of guggul produce lower cholesterol levels and lessening in serum turbidity2 .The cholesterol lowering effects have been seen in monkeys kept on a high cholesterol diet, the results being comparable to those of Atromid-S 3. it has a high antiinflammatory potential against Brownlee's formaldehyde induced arthritis in albino rats4.
THERAPEUTIC USES Indicated in rheumatic disorders and obesity.
REFERENCES
  1. Patil, N.D. et al: Tetrahedron 8 :2341 (1972)
  2. Tripathi, S.N. Et al : J.Res.INd. Med.Res. 57: 900 (1969)
  3. Das, D. et al: Ind.J.Pharmacol 5 : 223 (1973)
  4. Gujral, M.L. et al : Ind. J.Physiol.Pharmacol. 4 : 267 (1960)
  5. Selected Medicinal Plants of India, CHEMIXCIL, Mumbai (1992)
SPECIFICATIONS:

GUGGUL EXTRACT
(Commiphora mukul)

General Information:

Type of extract : Dry powder
Plant Parts used Gum Exudate
source Wild crafted
Shelf life : 24 months unopened
Storage : Keep in a cool, dry place protected from moisture and heat
Active ingredient/s Guggul sterones
Method of analysis HPLC / HPTLC

Analytical Specifications :

Description : Pale yellow powder, hygroscopic.
Organoleptic characters : Characteristic odour and taste
Loss on drying : Not more than 5% W/W
Lead : Not more than 10 PPM
Arsenic : Not more than 2 PPM
Heavy metals : Not more than 20 PPM
Assay
Guggul sterones content on dry basis by HPLC / HPTLC : Not less than 3% W/W
Microbiological Profile :
Total bacterial count : Not more than 3000 CFU/gm
Yeasts and Moulds : Not more than 100 CFU/gm
E.coli : Absent
S.aureus : Absent
Salmonella typhi : Absent
Pseudomonas aeruginose : Absent

 

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