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Holarrhena antidysenterica
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| CHEMICAL
COMPOSITION |
Around 30 alkaloids have been isolated from
the plant, mostly from the bark. These include conessine, kurchine, kurchicine,
holarrhimine, conarrhimine, conaine, conessimine, iso-conessimine, conimine, holacetin and
conkurchin1. |
| PHARMACOLOGY |
Conessine from the bark killed free living
amoebae and also kills entamoeba histolytica in the dysenteric stools of experimentally
infected kittens.It is markedly lethal to the flagellate protozoon. It is antitubercular
also 3. Conkurchine is hydrochloride hypotensive and vasodilator
4. |
| THERAPEUTIC
USES |
The bark is used as an astringent,
anthelmintic, antidontalgic,stomachic, febrifuge, antidropsical, diuretic, in piles,
colic, dyspepsia, chest affections and as a remedy in diseases of the skin and spleen 5
. It is a well known drug for amoebic dysentery and other gastric disorders 6
. It is also indicated in diarrhoea, indigestion, flatulence and colic 7
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| REFERENCES |
- Indian J. Chem., 1981, 20B: 62.
- Chopra, R.N,: Indigenous Drugs of India, Academic Publishers,
Calcutta (1982).
- J.Pharm. (London), 1049, 1:340.
- Proc. Rajasthan Acad. Sci., 1961, 8:94.
- Dictionary of Indian Medicinal Plants,CIMAP, Lucknow(1992)
- Singh, K.P.: Ancient Sci. Life 5:228 (1986).
- Selected Medicinal Plants of India, CHEMEXCIL, Mumbai (1982).
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| SPECIFICATIONS: HOLARRHENA
ANTIDYSENTERICA EXTRACT
General
Information:
| Type of extract |
: |
Dry powder |
| Plant parts used |
: |
Bark |
| Source |
: |
Wild crafted |
| Shelf life |
: |
24 months unopened |
| Storage |
: |
Keep in a cool, dry
place protected from moisture and heat |
| Active ingredient |
: |
Alkaloids |
| Method of analysis |
: |
Gravimetry/HPTLC |
Analytical
Specifications :
| Description |
: |
Dark brown powder |
| Organoleptic characters |
: |
Extremely bitter in taste with characteristic odour |
| Loss on drying |
: |
Not more than 5% W/W |
| Lead |
: |
Not more than 10 PPM |
| Arsenic |
: |
Not more than 2 PPM |
| Heavy metals |
: |
Not more than 20 PPM |
| Assay |
|
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Total alkaloids content on dry basis by
Gravimetry /HPTLC |
: |
Not less than 2.5% W/W |
| Microbiological profile |
: |
|
| Total bacterial count |
: |
Not more than 3000 CFU/gm |
| Yeasts and moulds |
: |
Not more than 100 CFU/gm |
| E.coli |
: |
Absent |
| S.aureus |
: |
Absent |
| Salmonella typhi |
: |
Absent |
| Pseudomonas aeruginose |
: |
Absent |
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