|
|
|
Piper
nigrum |
|
| CHEMICAL
COMPOSITION |
The fruit
contains volatile oil, piperine and a resin 1. |
| PHARMACOLOGY |
The fruit extract showed
selective anthelmintic activity against cestodes2. Piperine displayed CNS depressant
activity in mice, antipyretic effect in rabbits given typhoid vaccine, and analgesic
activity in tail clip pressure in mice3.
It also showed febrifugal activity in rats4.
|
| THERAPEUTIC
USES |
It is prescribed in dyspepsia,
flatulence, diarrhoea and as a febrifuge in intermittent fevers5. It is also indicated
in viral hepatitis6. |
| REFERENCES |
- Atal, C.K. et al.: Lloydia
38 :256(1962)
- Srivastava, M.C. et al.:
Ind.J.Pharm.30:65 (1968)
- Lee Eun Bang et
al.:Arch.Parmacol.Res.7:127 (1984)
- Purseglove,J.N.et
al.:Spices, Vol.2.Longman London(1981), cited in 8
- Tathed, P.S. et al.:Personal
Communication.
- Selected Medicinal Plants of
India, CHEMEXCIL (1992)
|
| SPECIFICATIONS: PIPER
NIGRUM EXTRACT
General
Information:
| Type of extract |
: |
Dry powder |
| Plant Parts used |
|
Fruits |
| source |
|
Wild crafted |
| Shelf life |
: |
24 months unopened |
| Storage |
: |
Keep in a cool, dry
place protected from moisture and heat |
| Active ingredient |
|
Piperine |
| Method of analysis |
|
HPLC / HPTLC |
Analytical
Specifications :
| Description |
: |
Light yellow crystalline powder. |
| Organoleptic characters |
: |
Highly pungent in taste with characteristic odour. |
| Loss on drying |
: |
Not more than 5% W/W |
| Lead |
: |
Not more than 10 PPM |
| Arsenic |
: |
Not more than 2 PPM |
| Heavy metals |
: |
Not more than 20 PPM |
| Assay |
|
|
| Piperine content on dry basis by HPLC /HPTLC |
: |
Not less than 95% W/W |
| Microbiological Profile |
: |
|
| Total bacterial count |
: |
Not more than 3000 CFU/gm |
| Yeasts and Moulds |
: |
Not more than 100 CFU/gm |
| E.coli |
: |
Absent |
| S.aureus |
: |
Absent |
| Salmonella typhi |
: |
Absent |
| Pseudomonas aeruginose |
: |
Absent |
| * Piper nigrum extract is also available as
thick paste. |
|
|
